Start with the dates
Check whether shifting departure or return by a day changes both air fares and hotel rates. The best-value combination is not always the cheapest flight paired with the cheapest room.
Check what is included
Review baggage, room type, breakfast, local taxes, airport transfers and cancellation conditions. These can materially change the final cost.
Choose the hotel by itinerary
If most activities are concentrated in one part of the city, a slightly higher room price can be worthwhile if it reduces daily transport and saves time.